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| Paper IPM / Cognitive / 7466 |
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Nitric oxide (NO) may alter dopamine release in brain. Activation of D2 dopamine receptors may suppress NO synthase, and inhibition of NO synthase prevents behaviours induced by psychostimulants. We have investigated the modulatory actions of the precursor of NO synthesis (L-arginine) and the broad spectrum NO synthesis inhibitor L-nitoarginine methylester (L-NAME) on apomorphine-induced behaviours in the rat. Apomorphine was injected subcutaneously, and behaviours induced by the drug were examined in the presence or absence of intracerebroventricular (ICV) administration of L-arginine and L-NAME. Our data indicate L-arginine or L-NAME treatment decreased licking, and yawning, but not penile erection induced by apomorphine. Conclusion; apomorphine-induced behaviours may be modulated by NO levels
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