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Paper   IPM / Cognitive Sciences / 16554
School of Cognitive Sciences
  Title:   Frontotemporal coordination predicts working memory performance and its local neural signatures
1.  E. Rrzayat
2.  M. A. Dehaqani
3.  K. Clark
4.  Z. Bahmani
5.  T. Moore
6.  B. Noudoost
  Status:   Published
  Journal: Nature Communications
  Vol.:  12
  Year:  2021
  Supported by:  IPM
Neurons in some sensory areas reflect the content of working memory (WM) in their spiking activity. However, this spiking activity is seldom related to behavioral performance. We studied the responses of inferotemporal (IT) neurons, which exhibit object-selective activity, along with Frontal Eye Field (FEF) neurons, which exhibit spatially selective activity, during the delay period of an object WM task. Unlike the spiking activity and local field potentials (LFPs) within these areas, which were poor predictors of behavioral performance, the phase-locking of IT spikes and LFPs with the beta band of FEF LFPs robustly predicted successful WM maintenance. In addition, IT neurons exhibited greater object-selective persistent activity when their spikes were locked to the phase of FEF LFPs. These results reveal that the coordination between prefrontal and temporal cortex predicts the successful maintenance of visual information during WM.

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