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Paper   IPM / Cognitive Sciences / 13206
School of Cognitive Sciences
  Title:   Evaluation of functional relationship between mouse hippocampal cholinergic and nitrergic systems in anxiogenic-like behavior
1.  M.R. Zarrindast
2.  M. Piri
3.  M. Bananej
4.  Z. Shahab
5.  M. Zahmatkesh
  Status:   Published
  Journal: Behavioral Pharmacology
  Vol.:  24
  Year:  2013
  Pages:   229-236
  Supported by:  IPM
Although a body of evidence shows the crucial role of hippocampal nitrergic and cholinergic systems in the modulation of anxiety, little is known about their functional relationship with regard to anxiety. The present study investigated the relationship between intra-CA1 administration of a nicotinic acetylcholine receptor antagonist (mecamylamine) and a nitric oxide synthase inhibitor [Nω-nitro-L-arginine methyl ester (L-NAME)] or its precursor (L-arginine) in anxietyrelated behaviors. Mice received bilateral intra-CA1 injections of either L-NAME or L-arginine in the presence of mecamylamine and were subsequently tested in the elevated plus maze. A dose of 0.5 μg/0.5 μl mecamylamine bilaterally administered into CA1 did not change the percentage of open arm time (

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