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Paper   IPM / Cognitive Sciences / 13204
School of Cognitive Sciences
  Title:   Interaction between Morphine and Noradrenergic System of Basolateral Amygdala on Anxiety and Memory in the Elevated Plusmaze Test Based on a Test-retest Paradigm
1.  F. Valizadegan
2.  S. Oryan
3.  M. Nasehi
4.  M.R. Zarrindast
  Status:   Published
  Journal: Archives of Iranian Medicine
  Vol.:  16
  Year:  2013
  Pages:   281-287
  Supported by:  IPM
BACKGROND: The amygdala is the key brain structure for anxiety and emotional memory storage. We examined the involvement of β-adrenoreceptors in the basolateral amygdala (BLA) and their interaction with morphine in modulating these behaviors. The elevated plus-maze has been employed for investigating anxiety and memory. Male Wistar rats were used for this test. We injected morphine (4, 5, and 6 mg/kg) intraperitoneally, while salbutamol (albuterol) (1, 2, and 4 μg/rat) and propranolol (1, 2, and 4 μg/rat) were injected into the BLA. Open- arms time percentage (Intraperitoneal injection of morphine (6 mg/kg) had an anxiolytic-like effect and improvement of memory. The highest dose of salbutamol decreased the anxiety parameters in test session and improved the memory in retest session. Coadministration of salbutamol and ineffective dose of morphine presenting anxiolytic response. In this case, the memory was improved. Intra-BLA administration of propranolol (4 μg/rat) decreased We found that opioidergic and β-adrenergic systems have the same effects on anxiety and memory in the BLA; but these effects are independent of each other.

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