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Paper   IPM / Cognitive Sciences / 11819
School of Cognitive Sciences
  Title:   Reduction of negative afterimage duration in parkinson's disease patients: A possible role for dopaminergic deficiency in the retinal interplexiform sell layer
1.  Fatemeh Khadjevand
2.  Sohrab Shahzadi
3.  Abdolhossein Abbasian
  Status:   Published
  Journal: Vision
  Vol.:  50
  Year:  2010
  Pages:   279-283
  Supported by:  IPM
Dopaminergic deficiency may affect Parkinson?s disease patients (PD) in the central as well as the peripheral tissues. In the retina, the neuromodulatory role of the dopaminergic Interplexiform cell layer (IP) plays a major role in the retinal light adaptation and may account for the duration of the negative afterimage. Here we present results showing a significant reduction of negative afterimage duration in PD patients. This supports the hypothesis that the retinal dopaminergic system may be the main cause for the long duration of negative afterimage. We suggest that the observed reduction of afterimage duration is due to possible dopaminergic deficiency in patients with Parkinson?s disease.

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